FASCINATION ABOUT SBS88

Some strands of Escherichia coli can contain the polyketide synthetase (pks) island that encodes colibactin, a genotoxic compound which will alkylate DNA on adenine residues and induce position mutations with a certain signature12,thirteen (COSMIC SBS88). In addition, exposure to pks+ E. coli generates a characteristic limited indel signature (COSM